Hop Extract (Xanthohumol 20%-98% & 8-Prenylnaringenin) — Bulk Supply from Certified Manufacturer
Nutrayours supplies pharmaceutical and nutraceutical-grade Hop Extract providing two distinct standardized active compounds: Xanthohumol (XN) at 20%–98% purity and 8-Prenylnaringenin (8-PN, CAS 53846-50-7), both verified by HPLC testing. Sourced from Humulus lupulus L. (family Cannabaceae), our extracts meet BP, USP, and Cosmetics grade standards, making them suitable for women’s health, cognitive health, metabolic wellness, and sleep support supplement formulations globally.
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | Hop Extract / Xanthohumol / 8-Prenylnaringenin (8-PN) |
| Latin Name | Humulus lupulus L. |
| Active Compounds | Xanthohumol (XN) 20%-98% / 8-Prenylnaringenin (8-PN) |
| Molecular Formula (8-PN) | C20H20O5 |
| Molecular Mass (8-PN) | 340.4 |
| CAS No. (8-PN) | 53846-50-7 |
| Test Method | HPLC |
| Appearance | Brown to orange powder |
| Standard | BP / USP / Cosmetics Grade |
| Shelf Life | 24 months |
| Sample Size | 5-20g |
| Minimum Bulk Order | 25kg |
| Lead Time | 3 days (sample) / 7 days (bulk) |
Packaging Options
- 1–5kg: Aluminum foil bag
- 25kg: Paper drum with double inner plastic bags
- Custom packaging available on request
Understanding the Two Key Bioactives in Hop Extract
Hops (Humulus lupulus L.) contain two distinct phytochemicals of significant nutraceutical interest, each with different mechanisms of action and application profiles:
Xanthohumol (XN) is the principal prenylated chalcone in hops, found in concentrations of up to 1% in raw hops but concentrated to 20%–98% in standardized extracts. It has attracted substantial research interest for its antioxidant, anti-inflammatory, neuroprotective, and metabolic health properties. Nutrayours supplies Xanthohumol at multiple standardization levels from 20% to 98% to meet different formulation and cost requirements.
8-Prenylnaringenin (8-PN) is a prenylated flavanone and one of the most potent phytoestrogens identified in plants — significantly more estrogenic than the classical phytoestrogens genistein and daidzein. It is formed through the metabolic conversion of Xanthohumol and demonstrates particularly strong affinity for estrogen receptor alpha (ERα), giving it distinct applications in women’s health and bone health formulations.
Clinical Evidence & Key Benefits
Xanthohumol (XN) — Longevity, Cognitive & Metabolic Health
Xanthohumol has generated growing research interest as a longevity and neuroprotective ingredient. Key evidence includes neuroprotective activity — XN crosses the blood-brain barrier and reduces neuroinflammation, protecting against oxidative stress-induced neuronal damage relevant to cognitive aging and neurodegenerative conditions. It also demonstrates potent antioxidant activity, scavenging multiple types of free radicals and reducing systemic oxidative stress more effectively than many conventional antioxidants. Research published in 2025 confirms XN’s metabolic health benefits, including support for healthy glucose metabolism, lipid regulation, and reduction of obesity-related inflammation. At low doses (0.001–5 µM), XN has been shown to improve mitochondrial function — a key mechanism in longevity and healthy aging research.
8-Prenylnaringenin (8-PN) — Women’s Health & Bone Health
8-PN is the most potent phytoestrogen yet identified, with significantly stronger estrogenic activity than genistein or daidzein at equivalent doses. Key clinical evidence includes menopause symptom relief, where clinical studies confirm 8-PN effectively reduces hot flashes and other menopausal vasomotor symptoms, with effects comparable to low-dose conventional hormone therapy in some trials. It also supports bone health by promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption via ERα — a dual mechanism that makes it particularly valuable for postmenopausal bone health formulations. Research also confirms 8-PN’s potential in oral health applications, where it and tamoxifen have been shown to inhibit the shedding of irradiated epithelial cells and increase the latency period of radiation-induced oral mucositis.
Sleep Support & Nervous System
Hops have a centuries-long history of use as a natural sedative. Modern research confirms the calming and hypnotic effects of hop extract on the central nervous system, supporting its use in sleep quality and stress relief formulations. Combined with valerian root, hop extract demonstrates synergistic sedative effects well-documented in clinical literature.
Digestive & Antimicrobial Health
Hop Extract demonstrates broad-spectrum antimicrobial activity against multiple bacterial strains including Bacillus anthracis, Corynebacterium diphtheriae, Diplococcus pneumoniae, and Staphylococcus aureus. It also helps stimulate appetite, reduce flatulence, and relieve intestinal cramps — supporting gastrointestinal health applications.
Industry Applications
Hop Extract (Xanthohumol / 8-Prenylnaringenin) is used across multiple product categories:
Nutraceuticals & Dietary Supplements: Capsules and tablets for women’s health, menopause support, bone health, sleep quality, cognitive health, metabolic wellness, and longevity formulations.
Functional Foods & Beverages: Naturally derived from hops, Xanthohumol is compatible with brewing applications and functional beverage formulations.
Cosmetics: Antioxidant and anti-inflammatory properties support topical skin care applications.
Pharmaceutical: Research applications targeting menopausal hormone therapy alternatives, bone loss prevention, and neuroprotection.
Why Source Hop Extract from Nutrayours?
Nutrayours is an ISO 9001 certified plant extract manufacturer based in Changsha, China, established in 2014. We supply Hop Extract (Xanthohumol 20%–98% and 8-Prenylnaringenin) to nutraceutical brands, women’s health supplement companies, and private label manufacturers across Europe, the Middle East, and Southeast Asia.
- ISO 9001 certified quality management system
- Halal certified — suitable for Muslim-majority markets
- SC manufacturing certification
- Full COA for every batch — XN and 8-PN content, heavy metals, microbiological testing
- Free samples: 5-20g before bulk commitment
- Sample delivery: 3 days. Bulk orders: within 7 days
- Minimum bulk order: 25kg
- Factory-direct pricing
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Request a Free Sample or Bulk Quote
Whether you are developing a women’s health supplement, sleep support formula, cognitive health product, or longevity formulation, our team is ready to support your sourcing needs.
Contact us today — we respond within 12 hours. Free samples: 5-20g Bulk orders from 25kg | Ships within 7 days
