Sophora Japonica Extract — Quercetin Dihydrate 95% HPLC / 98% UV | Powder & Granular
Nutrayours is a quercetin dihydrate supplier providing Sophora Japonica Extract standardized for Quercetin Dihydrate 95% (HPLC) and 98% (UV), available in both fine powder and granular formats for supplement and pharmaceutical manufacturers worldwide.
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | Sophora Japonica Extract / Quercetin Dihydrate |
| Latin Name | Sophora japonica L. |
| Plant Part Used | Flower & Flower Bud |
| Active Ingredient | Quercetin Dihydrate |
| Specification | 95% (HPLC) / 98% (UV) |
| CAS No. | 117-39-5 |
| Molecular Formula | C15H10O7·2H2O |
| Molecular Mass | 338.27 g/mol |
| Extraction Method | Ethanol extraction |
| Appearance | Light yellow to greenish-yellow powder or granules |
| Formats Available | Fine Powder (80 mesh) / Granular |
| Standard | BP / USP / ChP |
| Shelf Life | 24 months |
| Sample Size | 5-20g |
| Minimum Bulk Order | 25kg |
| Supply Capacity | 4,000 kg per week |
| Lead Time | 3 days (sample) / 7 days (bulk) |
Packaging Options
- 1–5kg: Aluminum foil bag
- 25kg: Paper drum with double inner plastic bags
- Custom packaging available on request
What Is Sophora Japonica Extract (Quercetin Dihydrate)?
Sophora japonica L., commonly known as the Japanese pagoda tree or Chinese scholar tree, is a deciduous tree widely distributed across China and East Asia. Its flowers and flower buds have been used for centuries in Traditional Chinese Medicine (TCM) to improve circulation, reduce bleeding, lower blood pressure, and treat headaches and cardiovascular conditions.
The primary bioactive in Sophora Japonica Extract is Quercetin, specifically in its dihydrate form (Quercetin Dihydrate, C15H10O7·2H2O). Quercetin is one of the most abundant and widely studied flavonoids in nature, found in many fruits, vegetables, and grains. However, Sophora japonica flower buds represent the most concentrated and commercially viable natural source for high-purity quercetin extraction, making them the global industry standard raw material for pharmaceutical and nutraceutical quercetin production.
Why Quercetin Dihydrate — Not Anhydrous Quercetin
Quercetin exists in multiple forms, but Quercetin Dihydrate is the industry-preferred specification for supplement and pharmaceutical formulations for two key reasons. First, superior bioavailability — the dihydrate form is more bioavailable than anhydrous quercetin, making it the go-to specification for finished product formulators seeking efficacy at lower inclusion rates. Second, superior stability — the dihydrate crystal structure provides greater chemical stability during processing, storage, and formulation compared to anhydrous forms, extending product shelf life and reducing degradation risk.
Why Dual Specification (98% UV / 95% HPLC) Matters
Our Sophora Japonica Extract is standardized to both 98% UV and 95% HPLC — the two testing methods used in different pharmacopoeia monographs and market regulatory frameworks. UV testing at 98% aligns with traditional pharmacopoeia specifications and is widely accepted in food and supplement markets. HPLC testing at 95% provides precise individual compound quantification, picking up trace impurities that UV cannot detect, and is the gold standard for pharmaceutical-grade quercetin documentation. Supplying both specifications on the COA gives formulators maximum regulatory flexibility across European, Middle Eastern, and Southeast Asian markets.
Powder vs Granular — Choosing the Right Format
Nutrayours supplies Quercetin Dihydrate in two physical formats to meet different manufacturing needs:
Fine Powder (80 Mesh): Standard specification for encapsulation, tablet compression, and general supplement manufacturing. 80 mesh particle size ensures excellent blend uniformity and dissolution characteristics suitable for most formulation types.
Granular Format: Purpose-engineered for high-volume tableting, capsule filling, and dry blend manufacturing. The granular format delivers consistent particle size distribution, superior flowability, and significantly reduced dusting during manufacturing compared to fine powder. For manufacturers processing large batch volumes, granular quercetin reduces material loss, improves blend uniformity, and decreases equipment maintenance requirements — making it the preferred specification for industrial-scale supplement production.
Clinical Evidence & Key Benefits
Antioxidant & Anti-Inflammatory Protection
Quercetin is one of the most potent natural antioxidants identified in plant science, with broad-spectrum free radical scavenging activity. Multiple clinical and preclinical studies confirm its ability to reduce systemic oxidative stress, inhibit NF-κB inflammatory signaling, reduce pro-inflammatory cytokine production, and protect cellular DNA from oxidative damage. These properties underpin quercetin’s relevance across virtually every major supplement category.
Cardiovascular Health
Quercetin has demonstrated multiple cardiovascular benefits in clinical research, including reduction of blood pressure in hypertensive individuals (meta-analysis of 7 RCTs confirming significant reductions in systolic and diastolic BP), improvement of endothelial function and blood flow, reduction of LDL oxidation, inhibition of platelet aggregation, and prevention of atherosclerotic plaque formation. These combined cardiovascular benefits position Sophora Japonica Extract as a premium ingredient for heart health formulations.
Immune Support & Antiviral Activity
Quercetin has emerged as one of the most studied natural immune-support ingredients, with documented ability to modulate innate and adaptive immune responses, inhibit viral replication through interference with viral proteases, reduce severity and duration of upper respiratory infections, and enhance the efficacy of zinc supplementation by acting as a zinc ionophore — facilitating cellular zinc uptake. Post-pandemic consumer awareness of quercetin’s immune applications has significantly expanded market demand for this ingredient globally.
Longevity & Senolytic Activity
As highlighted at Vitafoods Europe 2026, quercetin is one of the key ingredients driving the longevity supplement category. Combined with other senolytics such as fisetin, quercetin has demonstrated the ability to selectively eliminate senescent cells — the “zombie cells” that accumulate with aging and drive chronic inflammation. This senolytic application represents one of the most exciting emerging categories in the global supplement market, with quercetin positioned as a cost-effective, well-evidenced ingredient for longevity stacks.
Cognitive Health & Neuroprotection
Quercetin crosses the blood-brain barrier and demonstrates neuroprotective properties, including reduction of neuroinflammation, protection against amyloid-beta accumulation, and support for healthy cognitive aging. These cognitive applications add another dimension to quercetin’s formulation versatility.
Women’s Health & Hormonal Support
Quercetin’s anti-inflammatory and antioxidant properties support women’s health applications, including the reduction of menstrual pain and inflammation, support for healthy estrogen metabolism, and potential benefits for polycystic ovary syndrome (PCOS) through insulin-sensitizing and anti-inflammatory mechanisms.
Blood Sugar Management
Multiple studies confirm quercetin’s ability to improve insulin sensitivity, reduce postprandial blood glucose spikes, and protect pancreatic beta cells from oxidative damage — making it a relevant ingredient for metabolic health and blood sugar support formulations.
Industry Applications
Nutraceuticals & Dietary Supplements: Capsules and tablets for antioxidant support, cardiovascular health, immune support, longevity, cognitive health, women’s health, and metabolic wellness formulations.
Pharmaceutical: Anti-inflammatory and cardiovascular pharmaceutical preparations meeting BP/USP/ChP monograph requirements.
Functional Foods & Beverages: Natural antioxidant enrichment for health beverages, functional snacks, and nutraceutical food products.
Cosmetics: Antioxidant and anti-inflammatory ingredients in skin care formulations targeting oxidative stress and aging.
Why Source Quercetin Dihydrate from Nutrayours?
Nutrayours is an ISO 9001 certified plant extract manufacturer based in Changsha, China, established in 2014. We supply Quercetin Dihydrate (Sophora Japonica Extract) to pharmaceutical companies, nutraceutical brands, and private label manufacturers across Europe, the Middle East, and Southeast Asia.
- ISO 9001 certified quality management system
- Halal certified — suitable for Muslim-majority markets
- SC manufacturing certification
- Full COA for every batch — quercetin content by both HPLC and UV, heavy metals, microbiological testing
- Both powder and granular formats are available from stock
- Free samples: 5-20g before bulk commitment
- Sample delivery: 3 days. Bulk orders: within 7 days
- Minimum bulk order: 25kg
- Supply capacity: 300 kg per week
- Factory-direct pricing
Related Products
Longevity & Senolytic: Urolithin A | Spermidine HCl | Polydatin 98% | Ca-AKG | Betulinic Acid 98% | Wheat Germ Extract (Spermidine 1%)
Cardiovascular & Antioxidant: Grape Seed Extract (OPC 95%) | Green Tea Extract (EGCG 50%+) | Turmeric Root Extract (Curcumin 95%) | Hesperidin 90% | Rosemary Extract (Ursolic Acid 50%) | Coenzyme Q10
Immune Support: NAC (N-Acetyl-L-Cysteine) | Goldenrod Extract | Atractylodes Extract | Bromelain | Panax Ginseng Extract
Women’s Health: Flaxseed Extract (SDG 20%-60%) | DIM (Diindolylmethane) | Hop Extract (Xanthohumol 20%-98%) | Genistein |Honokiol 98%
Cognitive Health: Baicalein 98% | GABA | PEA (Palmitoylethanolamide) | Ginkgo Biloba Extract | Polydatin 98%
Request a Free Sample or Bulk Quote
Whether you need fine powder for standard encapsulation or granular format for high-volume tableting and capsule filling, our team is ready to support your sourcing requirements.
Contact us today — we respond within 12 hours. Free samples: 5-20g (powder or granular — please specify) Bulk orders from 25kg | Ships within 7 days
